2014 - Criteria for the Diagnosis of Fibromyalgia

A Cytokine/Chemokine Multiplex Assay That Is Sensitive and Specific For Fibromyalgia Compared To Controls, Systemic Lupus Erythematosus, and Rheumatoid Arthritis. Daniel J. Wallace1, Igor Gavin2, Oleksiy Karpenko2 and Bruce S. Gillis2. 1Cedars-Sinai Medical
Center, Los Angeles, CA, 2University of Illinois College of Medicine atChicago, Chicago, IL.

Background/Purpose: Fibromyalgia (FM) is a chronic pain and fatigue syndrome that affects about 6 million adults in the United States. The clinical diagnosis of FM has been based on subjective evaluations paired with the exclusion of other diseases. No confirmatory objective

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Fibromyalgia criteria and severity scales for clinical and epidemiological studies: a modification of the ACR Preliminary Diagnostic Criteria for Fibromyalgia.

Fibromyalgia criteria and severity scales for clinical and epidemiological studies: a modification of the ACR Preliminary Diagnostic Criteria for Fibromyalgia.
Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, et al
J Rheumatol (2011 Jun) 38(6):1113-22
OBJECTIVE: To develop a fibromyalgia (FM) survey questionnaire for epidemiologic and clinical studies using a modification of the 2010 American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia (ACR 2010). We also created a new FM symptom scale to further characterize FM severity.

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Fibromyalgia syndrome: Canadian clinical working case definition, diagnostic and treatment protocols- A consensus document

Fibromyalgia syndrome: Canadian clinical working case definition, diagnostic and treatment protocols- A consensus document

J Musculoskeletal Pain, 2004; 11(4): 3-107
Jain AK, Carruthers BM, van de Sande MI, Barron SR, Donaldson CCS, Dunne JV, Gingrich E, Heffez DS, Leung FYK, Malone DG, Romano TJ, Russell IJ, Saul D, Seibel DG.

Background: There has been a growing recognition of the need for information about objective abnormalities in people with the fibromyalgia syndrome [FMS] and for an integrated approach to its diagnosis and management by primary care physicians.

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The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia

The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee

Wolfe F, Smythe HA, Yunus MB, et al

Arthritis Rheum (1990 Feb) 33(2); 160-72

To develop criteria for the classification of fibromyalgia, we studied 558 consecutive patients: 293 patients with fibromyalgia and 265 control patients. Interviews and examinations were performed by trained, blinded assessors.

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Fibromyalgia: more than just a musculoskeletal disease

Am Fam Physician. 1995 Sep 1;52(3):843-51, 853-4.
Clauw DJ.


Fibromyalgia is a common condition characterized by diffuse musculoskeletal pain and fatigue. The syndrome is defined by the presence of musculoskeletal tender points on physical examination. Additionally, persons with this syndrome have a high incidence of headaches, ocular and vestibular complaints, paresthesias, esophageal dysmotility, "allergic" symptoms, irritable bowl syndrome, genitourinary symptoms and affective disorders. Recent research has revealed a number of objective biochemical, hormonal and neurotransmitter abnormalities associated with fibromyalgia, making it a clearly identifiable condition. These abnormalities may clarify our understanding of the pathogenesis and treatment of fibromyalgia.